rs13229

This is a synonymous variant in the IFI35 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of N-myc-interactor in blood serum

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele T

OR 1.12

p 7.0e-27

N 466

Small GWAS

African American or Afro-Caribbean

About IFI35

Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of defense response. Located in several cellular components, including cytosol; extracellular space; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

View all IFI35 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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