rs13230509

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GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood urea nitrogen amount

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.05

p 4.0e-125

N 492,819

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.06

p 2.0e-109

N 418,647

Major Consortium StudyLarge GWAS

European

Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)

Allele C

OR 0.01

p 2.0e-17

N 58,406

Large GWAS

East Asian

serum urea amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.05

p 2.0e-107

N 394,642

Large GWAS

European

glomerular filtration rate

Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)

Allele C

OR 0.01

p 1.0e-102

N 1,004,040

Large GWAS

European

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele C

OR 0.01

p 7.0e-62

N 567,460

Large GWAS

European

Hellwege JN et al. “Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.” Nature Communications 10(1):3842 (2019)

Allele C

OR 0.01

p 4.0e-37

N 280,722

Major Consortium StudyLarge GWAS

multi-ancestry

Kintu C et al. “Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function.” Bmc Genomics 24(1):496 (2023)

Allele C

OR —

p 5.0e-9

N 80,027

Meta-analysisLarge GWAS

African unspecified

Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)

Allele C

OR 0.50

p 4.0e-12

N 58,406

Large GWAS

East Asian

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.05

p 8.0e-17

N 55,243

Major Consortium StudyLarge GWAS

Hispanic or Latin American

serum creatinine amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 2.0e-75

N 421,910

Major Consortium StudyLarge GWAS

European

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele G

OR 0.04

p 2.0e-21

N 136,016

Large GWAS

multi-ancestry

uric acid measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.03

p 3.0e-58

N 473,241

Large GWAS

multi-ancestry

erythrocyte count

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.03

p 1.0e-40

N 503,987

Large GWAS

multi-ancestry

hematocrit

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 6.0e-25

N 407,852

Major Consortium StudyLarge GWAS

European

hemoglobin measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 3.0e-15

N 407,894

Major Consortium StudyLarge GWAS

European

C-C motif chemokine 15 level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.04

p 1.0e-12

N 47,745

Large GWAS

European

systolic blood pressure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 1.0e-11

N 425,740

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs13230509

GWAS Catalog Trait Associations (12)

blood urea nitrogen amount

serum urea amount

glomerular filtration rate

serum creatinine amount

uric acid measurement

erythrocyte count

hematocrit

hemoglobin measurement

C-C motif chemokine 15 level

systolic blood pressure

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