rs1324007

This is a intron variant variant in the LRCH1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

JT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)

Allele T

OR 0.02

p 3.0e-15

N 252,730

Large GWAS

European, African unspecified, Hispanic or Latin American, South East Asian, South Asian

platelet volume

Yang Z et al. “Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.” Blood 143(15):1528-1538 (2024)

Allele C

OR 0.04

p 3.0e-9

N 71,605

Large GWAS

East Asian

About LRCH1

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]

View all LRCH1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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