rs13263601

This is a intron variant variant in the SGCZ gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele C
OR 0.01
p 2.0e-18
N 1,122,049
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.01
p 1.0e-12
N 394,642
Large GWAS
European
Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele C
OR 0.02
p 7.0e-10
N 342,566
Large GWAS
European
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Research that mentions this SNP (1)

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Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth
AssociationN=1,935Fasil Tekola-Ayele et al.(2021)· Human Genetics

A genome-wide admixture mapping study of 1,935 pregnant women from diverse ancestral backgrounds identified 10 African ancestry loci and 3 Amerindigenous ancestry loci associated with fetal growth measures. The lead variant rs13030825 (GALNT13) was strongly associated with longer humerus length in African Americans (β=0.44, P=6.25×10⁻⁶ at week 27; β=0.39, P=7.72×10⁻⁵ at week 40), with an FST of 0.55 between African and European populations. The findings identify ancestry-related maternal genetic loci influencing fetal growth across gestation.

Traits studied:Abdominal circumferenceBiparietal diameterBirth weightEstimated fetal weightFemur lengthFetal growth measuresHead circumferenceHumerus length
PubMedDOIMetascience Observatory

About SGCZ

The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]

View all SGCZ variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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