rs1330349

This variant is located in the TNC gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total hip arthroplasty, osteoarthritis

Boer CG et al. “Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.” Cell 184(18):4784-4818.e17 (2021)

Allele C

OR 1.10

p 6.0e-17

N 319,037

Large GWAS

European

osteoarthritis, hip

Tachmazidou I et al. “Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.” Nature Genetics 51(2):230-236 (2019)

Allele C

OR 1.08

p 4.0e-11

N 393,873

Major Consortium StudyLarge GWAS

European

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ClinVar annotation

Benign★☆☆☆

1 submitter

View on ClinVar →

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Research that mentions this SNP (1)

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Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease

AssociationN=2,409Mollie A. Minear et al.(2011)· Human Genetics

This study identifies polymorphic variants in tenascin-C (TNC) associated with atherosclerosis and coronary artery disease across three independent datasets. Three SNPs (rs3789875, rs12347433, and rs4452883) in high linkage disequilibrium were significantly associated with disease risk, with the strongest evidence for rs3789875 (p=2×10⁻⁶, OR=3.4-4.5) and rs12347433 (p=5×10⁻⁶, OR=1.3-1.69), a synonymous coding variant in exon 22.

Traits studied:AtherosclerosisCoronary artery diseaseCoronary heart disease

PubMed DOI Metascience Observatory

About TNC

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]