rs133885
This is a variant in the MYO18B gene that changes a glycine to an glutamate.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body height
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele G
OR 0.01
p 1.0e-16
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
atrial fibrillation
Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)
Allele A
OR 1.04
p 3.0e-16
N 1,650,345
Meta-analysisLarge GWAS
multi-ancestry
left atrial function
Pirruccello JP et al. “Deep learning of left atrial structure and function provides link to atrial fibrillation risk.” Nature Communications 15(1):4304 (2024)
Allele G
OR 0.05
p 4.0e-10
N 35,049
Large GWAS
electrocardiography
Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele G
OR 0.07
p 2.0e-33
N 63,706
Major Consortium StudyLarge GWAS
European, NR
left ventricular structural measurement
Ning C et al. “Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.” Nature Communications 14(1):7900 (2023)
Allele A
OR 0.05
p 4.0e-15
N 42,094
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
5 submitters2 publicationsKlippel-Feil anomaly-myopathy-facial dysmorphism syndrome
View on ClinVar →About MYO18B
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
View all MYO18B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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