MYO18B
myosin XVIIIB
Summary
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
Known Variants1,841 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs133856 | 22:26,142,492 | A/C | — | benign |
| rs61734946 | 22:26,157,068 | C/G | — | benign |
| rs770116314 | 22:26,157,075 | C/T | — | uncertain significance |
| rs775888404 | 22:26,157,076 | G/A | — | uncertain significance |
| rs376783532 | 22:26,157,079 | T/G | — | uncertain significance |
| rs371397750 | 22:26,157,080 | C/T | — | likely benign |
| rs139296373 | 22:26,157,081 | G/A | — | uncertain significance |
| rs1420397618 | 22:26,157,083 | C/T | — | likely benign |
| rs757976244 | 22:26,157,090 | G/T | — | pathogenic |
| rs376927643 | 22:26,157,112 | A/T | — | likely benign |
| rs17623980 | 22:26,157,144 | A/G | — | benign |
| rs6004758 | 22:26,157,299 | T/C | — | benign |
| rs133878 | 22:26,157,309 | G/C | — | benign |
| rs112270883 | 22:26,157,314 | C/A | — | benign |
| rs5761166 | 22:26,157,317 | G/C | — | benign |
| rs2331158 | 22:26,158,910 | C/G | — | benign |
| rs574599883 | 22:26,159,183 | G/A | — | likely benign |
| rs776692291 | 22:26,159,190 | C/T | — | likely benign |
| rs372043469 | 22:26,159,201 | C/T | — | uncertain significance |
| rs765079477 | 22:26,159,202 | G/A | — | uncertain significance |
| rs375159136 | 22:26,159,203 | G/A | — | likely benign |
| rs2517621785 | 22:26,159,214 | A/G | — | uncertain significance |
| rs2146603202 | 22:26,159,220 | C/T | — | uncertain significance |
| rs1568980418 | 22:26,159,227 | A/G | — | likely benign |
| rs113095510 | 22:26,159,230 | C/T | — | likely benign |
| rs79294358 | 22:26,159,232 | C/T | — | benign |
| rs780146591 | 22:26,159,233 | G/A | — | uncertain significance |
| rs749791709 | 22:26,159,235 | C/T | — | uncertain significance |
| rs2517622212 | 22:26,159,236 | C/T | — | likely benign |
| rs571003888 | 22:26,159,240 | C/T | — | uncertain significance |
| rs764193013 | 22:26,159,243 | C/T | — | uncertain significance |
| rs200574321 | 22:26,159,253 | T/C | — | conflicting classifications of pathogenicity |
| rs2517622449 | 22:26,159,255 | A/T | — | uncertain significance |
| rs771717793 | 22:26,159,261 | G/T | — | uncertain significance |
| rs1435887379 | 22:26,159,262 | G/A | — | uncertain significance |
| rs1474125306 | 22:26,159,265 | G/A | — | uncertain significance |
| rs746711853 | 22:26,159,270 | A/G | — | uncertain significance |
| rs2517622850 | 22:26,159,276 | C/T | — | pathogenic |
| rs375181150 | 22:26,159,278 | A/C | — | uncertain significance |
| rs1318966396 | 22:26,159,285 | C/T | — | uncertain significance |
| rs765087033 | 22:26,159,286 | G/A | — | uncertain significance |
| rs133885 | 22:26,159,289 | G/A | missense variant | benign |
| rs762675754 | 22:26,159,294 | G/A | — | uncertain significance |
| rs1375403546 | 22:26,159,305 | C/T | — | likely benign |
| rs200174012 | 22:26,159,313 | C/T | — | conflicting classifications of pathogenicity |
| rs750611108 | 22:26,159,314 | G/A | — | likely benign |
| rs2517623551 | 22:26,159,317 | A/T | — | uncertain significance |
| rs1440524516 | 22:26,159,320 | G/C | — | uncertain significance |
| rs1443918598 | 22:26,159,327 | C/T | — | pathogenic |
| rs1568980856 | 22:26,159,336 | G/C | — | uncertain significance |
| rs755446258 | 22:26,159,338 | C/T | — | likely benign |
| rs753058190 | 22:26,159,340 | C/T | — | uncertain significance |
| rs374693929 | 22:26,159,343 | C/T | — | conflicting classifications of pathogenicity |
| rs142414610 | 22:26,159,346 | C/T | — | uncertain significance |
| rs369047566 | 22:26,159,352 | G/A | — | uncertain significance |
| rs200238351 | 22:26,159,357 | G/T | — | likely pathogenic |
| rs133886 | 22:26,159,643 | A/C | — | benign |
| rs133889 | 22:26,160,105 | G/T | — | — |
| rs133890 | 22:26,160,161 | C/A | — | — |
| rs133901 | 22:26,163,996 | T/C | — | benign |
| rs1374857566 | 22:26,164,063 | G/T | — | likely benign |
| rs745580447 | 22:26,164,068 | G/A | — | likely benign |
| rs133902 | 22:26,164,079 | C/T | — | benign |
| rs371250005 | 22:26,164,084 | C/T | — | likely benign |
| rs1231246402 | 22:26,164,102 | C/T | — | likely benign |
| rs41281569 | 22:26,164,105 | A/G | — | benign |
| rs1005224060 | 22:26,164,111 | C/T | — | likely benign |
| rs368567040 | 22:26,164,132 | C/T | — | likely benign |
| rs1258830365 | 22:26,164,137 | C/G | — | uncertain significance |
| rs2517649383 | 22:26,164,150 | G/T | — | uncertain significance |
| rs552283952 | 22:26,164,162 | C/T | — | likely benign |
| rs759844976 | 22:26,164,163 | G/A | — | uncertain significance |
| rs765230212 | 22:26,164,176 | C/G | — | uncertain significance |
| rs761725266 | 22:26,164,179 | C/T | — | uncertain significance |
| rs370113994 | 22:26,164,190 | G/C | — | uncertain significance |
| rs150178966 | 22:26,164,192 | C/G | — | likely benign |
| rs989856968 | 22:26,164,193 | A/G | — | uncertain significance |
| rs2517649936 | 22:26,164,198 | G/A | — | likely benign |
| rs2086575959 | 22:26,164,201 | C/A | — | likely benign |
| rs2086576155 | 22:26,164,206 | A/T | — | uncertain significance |
| rs367932319 | 22:26,164,210 | C/T | — | likely benign |
| rs779373197 | 22:26,164,211 | G/A | — | likely benign |
| rs2086576523 | 22:26,164,219 | C/T | — | likely benign |
| rs372231956 | 22:26,164,220 | C/T | — | uncertain significance |
| rs754871127 | 22:26,164,221 | G/A | — | uncertain significance |
| rs778844679 | 22:26,164,222 | C/T | — | likely benign |
| rs1228527916 | 22:26,164,223 | A/C | — | uncertain significance |
| rs374273710 | 22:26,164,228 | C/T | — | likely benign |
| rs1479705925 | 22:26,164,229 | G/A | — | uncertain significance |
| rs1208692191 | 22:26,164,231 | C/G | — | uncertain significance |
| rs773128905 | 22:26,164,238 | C/A | — | uncertain significance |
| rs746067610 | 22:26,164,244 | A/G | — | uncertain significance |
| rs372175819 | 22:26,164,245 | C/G | — | uncertain significance |
| rs41281571 | 22:26,164,255 | C/T | — | likely benign |
| rs774965748 | 22:26,164,261 | G/C | — | uncertain significance |
| rs2145580764 | 22:26,164,269 | A/G | — | uncertain significance |
| rs370159021 | 22:26,164,271 | G/C | — | uncertain significance |
| rs2145580845 | 22:26,164,279 | C/A | — | likely benign |
| rs371265439 | 22:26,164,287 | C/T | — | uncertain significance |
| rs766086592 | 22:26,164,288 | G/A | — | likely benign |
Showing 100 of 1,841 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.