rs133902
This variant is located in the MYO18B gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
atrial fibrillation
Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)
Allele T
OR 0.04
p 1.0e-11
N 2,339,188
Large GWAS
multi-ancestry
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele T
OR 0.01
p 1.0e-9
N 1,486,094
Large GWAS
European
Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)
Allele T
OR 1.04
p 9.0e-10
N 1,030,836
Large GWAS
European
Cárcel-Márquez J et al. “A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.” Frontiers in Cardiovascular Medicine 9:940696 (2022)
Allele T
OR 0.01
p 9.0e-10
N 1,030,836
Large GWAS
European
left atrium capacity
Pirruccello JP et al. “Deep learning of left atrial structure and function provides link to atrial fibrillation risk.” Nature Communications 15(1):4304 (2024)
Allele C
OR 0.04
p 4.0e-9
N 35,049
Large GWAS
Brugada syndrome
Ishikawa T et al. “Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.” European Heart Journal 45(26):2320-2332 (2024)
Allele T
OR 1.20
p 5.0e-9
N 15,395
Large GWAS
multi-ancestry
Barc J et al. “Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.” Nature Genetics 54(3):232-239 (2022)
Allele T
OR 1.21
p 8.0e-9
N 12,821
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
5 submitters2 publicationsnot provided; Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome; not specified
View on ClinVar →About MYO18B
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
View all MYO18B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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