rs133890

This variant is located in the MYO18B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)

Allele C

OR 0.04

p 1.0e-29

N 1,840,341

Large GWAS

European

Left ventricular mass to end-diastolic volume ratio

Schmidt AF et al. “Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.” Science Advances 9(17):eadd4984 (2023)

Allele C

OR —

p 2.0e-9

N 32,520

Large GWAS

European

About MYO18B

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]

View all MYO18B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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