rs13428598
This is a intron variant variant in the ARHGAP15 gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
self reported educational attainment
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.02
p 1.0e-29
N 1,311,438
Large GWAS
European
mathematical ability
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.02
p 2.0e-19
N 811,539
Large GWAS
European
cognitive function measurement
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.02
p 1.0e-18
N 402,382
Large GWAS
European
diastolic blood pressure change measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 2.0e-18
N 609,486
Major Consortium StudyLarge GWAS
multi-ancestry
intelligence
Hill WD et al. “A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.” Molecular Psychiatry 24(2):169-181 (2019)
Allele T
OR 0.02
p 4.0e-13
N 248,482
Large GWAS
European
Davies G et al. “Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.” Nature Communications 9(1):2098 (2018)
Allele T
OR 5.94
p 3.0e-9
N 300,486
Large GWAS
European
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele T
OR 0.02
p 5.0e-11
N 254,641
Large GWAS
European
Coleman JRI et al. “Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.” Molecular Psychiatry 24(2):182-197 (2019)
Allele T
OR 5.85
p 5.0e-9
N 87,740
Meta-analysisLarge GWAS
European
health study participation
Tyrrell J et al. “Genetic predictors of participation in optional components of UK Biobank.” Nature Communications 12(1):886 (2021)
Allele C
OR 0.65
p 1.0e-12
N 300,639
Major Consortium StudyLarge GWAS
European
cognitive function measurement, self reported educational attainment
Demange PA et al. “Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.” Nature Genetics 53(1):35-44 (2021)
Allele C
OR 0.04
p 2.0e-11
N 257,700
Large GWAS
European
About ARHGAP15
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
View all ARHGAP15 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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