rs13429458

This is a downstream gene variant variant in the THADA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

polycystic ovary syndrome

Chen ZJ et al. “Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.” Nature Genetics 43(1):55-9 (2011)

Allele A

OR 1.49

p 2.0e-23

N 1,639

Large GWAS

East Asian

Shi Y et al. “Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.” Nature Genetics 44(9):1020-5 (2012)

Allele A

OR 1.49

p 4.0e-13

N 5,255

Large GWAS

East Asian

About THADA

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

View all THADA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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