Trait
SNPs associated with Polycystic ovary syndrome
66 genetic variants across 25 genes have been associated with Polycystic ovary syndrome in published research. Key genes include AOPEP, ARL14EP-DT, CHEK2.
Associated variants66 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs2178575 | ERBB4 | GWAS association (p=3.0e-14) | Meta-analysis |
| rs11031005 | — | GWAS association (p=9.0e-13) | Meta-analysis |
| rs12000707 | — | GWAS association (p=2.0e-12) | Meta-analysis |
| rs804279 | — | GWAS association (p=4.0e-12) | Meta-analysis |
| rs11225154 | — | GWAS association (p=5.0e-11) | Meta-analysis |
| rs9696009 | — | GWAS association (p=8.0e-11) | Meta-analysis |
| rs13164856 | — | GWAS association (p=1.0e-10) | Meta-analysis |
| rs1784692 | ZBTB16 | GWAS association (p=2.0e-10) | Meta-analysis |
| rs7563201 | — | GWAS association (p=3.0e-10) | Meta-analysis |
| rs8043701 | — | GWAS association (p=1.0e-09) | Meta-analysis |
| rs1795379 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs853854 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs569675099 | DENND1A | GWAS association (p=3.0e-09) | Meta-analysis |
| rs2271194 | ERBB3 | GWAS association (p=5.0e-09) | Meta-analysis |
| rs10739076 | — | GWAS association (p=3.0e-08) | Meta-analysis |
| rs7864171 | AOPEP | GWAS association (p=3.0e-08) | Meta-analysis |
| rs2228260 | XBP1 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs2234693 | ESR1 | Higher PCOS risk | Meta-analysis |
| rs1801282 | PPARG | Increased polycystic ovary syndrome risk | Meta-analysis |
| rs731236 | VDR | Increased polycystic ovary syndrome risk | Meta-analysis |
| rs9939609 | FTO | Increased polycystic ovary syndrome risk | Meta-analysis |
| rs1421085 | FTO | Increased risk of polycystic ovary syndrome | Meta-analysis |
| rs705702 | RAB5B | GWAS association (p=9.0e-26) | Large GWAS |
| rs13429458 | THADA | GWAS association (p=2.0e-23) | Large GWAS |
| rs12478601 | THADA | GWAS association (p=3.0e-23) | Large GWAS |
| rs1894116 | YAP1 | GWAS association (p=1.0e-22) | Large GWAS |
| rs7030193 | — | GWAS association (p=3.0e-22) | Large GWAS |
| rs2272046 | HMGA2 | GWAS association (p=2.0e-21) | Large GWAS |
| rs13405728 | LHCGR | GWAS association (p=8.0e-21) | Large GWAS |
| rs17879961 | CHEK2 | GWAS association (p=3.0e-20) | Large GWAS |
| rs2479106 | DENND1A | GWAS association (p=8.0e-19) | Large GWAS |
| rs10818854 | DENND1A | GWAS association (p=9.0e-18) | Large GWAS |
| rs182075939 | CHEK2 | GWAS association (p=2.0e-16) | Large GWAS |
| rs3802457 | AOPEP | GWAS association (p=5.0e-14) | Large GWAS |
| rs3729853 | GATA4 | GWAS association (p=1.0e-13) | Large GWAS |
| rs10993397 | — | GWAS association (p=5.0e-13) | Large GWAS |
| rs2268361 | FSHR | GWAS association (p=1.0e-12) | Large GWAS |
| rs1351592 | — | GWAS association (p=1.0e-12) | Large GWAS |
| rs3945628 | — | GWAS association (p=3.0e-12) | Large GWAS |
| rs10835638 | FSHB | Increased polycystic ovary syndrome risk | Large GWAS |
| rs4784165 | LOC107984901 | GWAS association (p=4.0e-11) | Large GWAS |
| rs7564590 | — | GWAS association (p=5.0e-11) | Large GWAS |
| rs78025940 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs7578655 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs13427822 | — | GWAS association (p=9.0e-10) | Large GWAS |
| rs11031006 | ARL14EP-DT | GWAS association (p=1.0e-09) | Large GWAS |
| rs4705862 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs6022786 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs11031002 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs76182733 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs1824982 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs562567873 | — | GWAS association (p=5.0e-09) | Large GWAS |
| rs2059807 | INSR | GWAS association (p=1.0e-08) | Large GWAS |
| rs17023134 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs7735176 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs55762028 | LOC105373727 | GWAS association (p=1.0e-08) | Large GWAS |
| rs1672716 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs1275468 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs9312937 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs17186366 | — | GWAS association (p=3.0e-08) | Large GWAS |
| rs145598156 | ZNRF3 | GWAS association (p=4.0e-08) | Large GWAS |
| rs10505648 | — | GWAS association (p=5.0e-08) | Large GWAS |
| rs113168128 | — | GWAS association (p=5.0e-08) | Large GWAS |
| rs2060941 | — | GWAS association (p=5.0e-08) | Small GWAS |
| rs806368 | CNR1 | Elevated risk in CC homozygotes | Candidate gene study |
| rs12720071 | CNR1 | Increased risk of hyperandrogenemia in Polycystic ovary syndrome | Candidate gene study |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.