rs145598156
This is a downstream gene variant variant in the ZNRF3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
polycystic ovary syndrome
Tyrmi JS et al. “Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome.” Human Reproduction (oxford, England) 37(2):352-365 (2022)
Allele T
OR 3.01
p 4.0e-8
N 141,355
Large GWAS
European
About ZNRF3
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNRF3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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