ZNRF3
zinc and ring finger 3
Summary
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants82 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1025350681 | 22:29,279,823 | C/G | — | likely benign |
| rs2518272951 | 22:29,279,901 | G/T | — | likely benign |
| rs2518272991 | 22:29,279,920 | A/G | — | uncertain significance |
| rs140353819 | 22:29,296,224 | G/A | intron variant | — |
| rs16986825 | 22:29,300,306 | C/T | regulatory region variant | — |
| rs75141640 | 22:29,319,152 | T/C | intron variant | — |
| rs7286026 | 22:29,333,861 | C/G | intron variant | — |
| rs28360615 | 22:29,338,656 | G/C | intron variant | — |
| rs5762907 | 22:29,339,085 | C/G | — | — |
| rs5752840 | 22:29,348,003 | C/T | regulatory region variant | — |
| rs2517532919 | 22:29,383,074 | T/C | — | pathogenic |
| rs77688610 | 22:29,415,725 | A/G | downstream gene variant | — |
| rs145598156 | 22:29,416,402 | C/T | downstream gene variant | — |
| rs2517585923 | 22:29,439,321 | C/T | — | pathogenic |
| rs371841167 | 22:29,440,768 | C/A | — | uncertain significance |
| rs757477292 | 22:29,440,813 | G/A | — | uncertain significance |
| rs772520393 | 22:29,440,868 | G/A | — | uncertain significance |
| rs1272768817 | 22:29,442,744 | T/C | — | uncertain significance |
| rs759184314 | 22:29,442,783 | G/A | — | uncertain significance |
| rs774958169 | 22:29,442,789 | G/A | — | uncertain significance |
| rs2517589745 | 22:29,442,837 | G/A | — | conflicting classifications of pathogenicity |
| rs2517589753 | 22:29,442,846 | G/A | — | pathogenic |
| rs2517591405 | 22:29,444,384 | G/A | — | pathogenic |
| rs2517591470 | 22:29,444,420 | G/A | — | pathogenic |
| rs758466692 | 22:29,444,428 | C/T | — | uncertain significance |
| rs2517591496 | 22:29,444,429 | C/G | — | pathogenic |
| rs372790629 | 22:29,444,458 | C/G | — | uncertain significance |
| rs375723111 | 22:29,444,459 | A/G | — | uncertain significance |
| rs2517591567 | 22:29,444,464 | C/T | — | pathogenic |
| rs759777321 | 22:29,445,277 | G/A | — | uncertain significance |
| rs2517592676 | 22:29,445,316 | A/G | — | uncertain significance |
| rs1467180040 | 22:29,445,457 | G/A | — | uncertain significance |
| rs34671303 | 22:29,445,468 | C/T | — | benign |
| rs966334000 | 22:29,445,482 | G/A | — | uncertain significance |
| rs745870049 | 22:29,445,580 | C/T | — | uncertain significance |
| rs2037144196 | 22:29,445,589 | T/C | — | uncertain significance |
| rs193004130 | 22:29,445,615 | G/C | — | uncertain significance |
| rs774552627 | 22:29,445,619 | G/A | — | uncertain significance |
| rs184228325 | 22:29,445,676 | G/A | — | uncertain significance |
| rs368294263 | 22:29,445,712 | G/A | — | likely benign |
| rs895328327 | 22:29,445,739 | G/A | — | uncertain significance |
| rs1157956367 | 22:29,445,767 | A/G | — | uncertain significance |
| rs200735359 | 22:29,445,841 | G/A | — | uncertain significance |
| rs201611146 | 22:29,445,852 | C/A | — | uncertain significance |
| rs758833950 | 22:29,445,950 | A/G | — | uncertain significance |
| rs2517594210 | 22:29,445,967 | C/T | — | uncertain significance |
| rs1475259968 | 22:29,446,013 | G/C | — | uncertain significance |
| rs770622005 | 22:29,446,051 | C/T | — | uncertain significance |
| rs199892375 | 22:29,446,070 | C/T | — | uncertain significance |
| rs367894542 | 22:29,446,073 | C/T | — | likely benign |
| rs375106696 | 22:29,446,249 | G/T | — | uncertain significance |
| rs1164907056 | 22:29,446,280 | G/T | — | uncertain significance |
| rs1415836727 | 22:29,446,328 | C/A | — | uncertain significance |
| rs201483333 | 22:29,446,367 | T/C | — | uncertain significance |
| rs189590137 | 22:29,446,401 | C/T | — | benign |
| rs1476849857 | 22:29,446,417 | C/T | — | uncertain significance |
| rs767740185 | 22:29,446,480 | G/A | — | uncertain significance |
| rs916576173 | 22:29,446,513 | T/C | — | uncertain significance |
| rs746840425 | 22:29,446,544 | G/A | — | uncertain significance |
| rs2123889068 | 22:29,446,577 | C/G | — | uncertain significance |
| rs779174815 | 22:29,446,584 | T/A | — | uncertain significance |
| rs1236517906 | 22:29,446,595 | C/T | — | uncertain significance |
| rs1375956230 | 22:29,446,637 | G/A | — | uncertain significance |
| rs1005949498 | 22:29,446,658 | C/G | — | uncertain significance |
| rs2517595843 | 22:29,446,670 | A/T | — | uncertain significance |
| rs771116760 | 22:29,446,709 | A/G | — | uncertain significance |
| rs779405955 | 22:29,446,771 | A/G | — | uncertain significance |
| rs199550379 | 22:29,446,787 | C/G | — | uncertain significance |
| rs769941403 | 22:29,446,802 | G/A | — | likely benign |
| rs764221550 | 22:29,446,835 | G/A | — | uncertain significance |
| rs368298573 | 22:29,446,861 | G/A | — | uncertain significance |
| rs1404645228 | 22:29,446,867 | G/A | — | uncertain significance |
| rs2517596218 | 22:29,446,870 | A/T | — | uncertain significance |
| rs772375384 | 22:29,449,570 | C/T | — | uncertain significance |
| rs536891882 | 22:29,449,600 | C/T | — | uncertain significance |
| rs62236881 | 22:29,450,193 | G/A | regulatory region variant | — |
| rs7290117 | 22:29,450,856 | C/G | — | — |
| rs2179129 | 22:29,450,923 | A/G | downstream gene variant | — |
| rs4823006 | 22:29,451,671 | A/G | regulatory region variant | — |
| rs3208800 | 22:29,451,793 | G/T | — | — |
| rs4823007 | 22:29,452,278 | A/T | — | — |
| rs3178915 | 22:29,453,027 | A/G | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.