rs2179129

This is a downstream gene variant variant in the ZNRF3 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele A
OR —
β 0.027
p 1.0e-15
N 252,375
Large GWAS
European

BMI-adjusted waist-hip ratio, physical activity measurement

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele A
OR 0.03
p 1.0e-9
N 156,653
Meta-analysisLarge GWAS
multi-ancestry

waist-hip ratio

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele A
OR 0.03
p 1.0e-8
N 143,480
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome‐wide association analysis of eating disorder‐related symptoms, behaviors, and personality traits
AssociationN=2,784Vesna Boraska et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Genome-wide association study of six eating disorder-related phenotypes (Drive for Thinness, Body Dissatisfaction, Bulimia, Weight Fluctuation, Breakfast Skipping, and Childhood Obsessive-Compulsive traits) across 2,698-2,967 individuals from TwinsUK discovery and two independent European replication cohorts. Meta-analysis identified eight genetic variants with suggestive evidence of association (P < 10^-5), including rs7624327 near CCNL1 (P=3.34E-06, OR=1.13 for Bulimia), rs1898111 in SEMA6D (P=7.66E-06, OR=0.872 for OCPD), and rs6894268 in RUFY1 (P=2.38E-06 for Body Dissatisfaction), but no signals reached genome-wide significance threshold (P < 5×10^-8).

Traits studied:Body DissatisfactionBreakfast SkippingBulimiaChildhood Obsessive-Compulsive Personality Disorder traitDrive for ThinnessWeight Fluctuation
PubMedDOIMetascience Observatory

About ZNRF3

Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ZNRF3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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