rs140353819
This is a intron variant variant in the ZNRF3 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
age at menopause
Ruth KS et al. “Genetic insights into biological mechanisms governing human ovarian ageing.” Nature 596(7872):393-397 (2021)
Allele A
OR 0.69
p 6.0e-20
N 201,323
Large GWAS
multi-ancestry
upper aerodigestive tract neoplasm
Lesseur C et al. “Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.” Plos Genetics 17(3):e1009254 (2021)
Allele A
OR 0.49
p 8.0e-12
N 75,848
Meta-analysisLarge GWAS
European
About ZNRF3
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNRF3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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