rs16986825
This is a regulatory region variant variant in the ZNRF3 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hemoglobin measurement
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele T
OR —
p 1.0e-27
N 746,431
Large GWAS
multi-ancestry
pancreatic carcinoma
Wolpin BM et al. “Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.” Nature Genetics 46(9):994-1000 (2014)
Allele T
OR 1.18
p 1.0e-8
N 6,785
Large GWAS
European
Klein AP et al. “Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.” Nature Communications 9(1):556 (2018)
Allele T
OR 1.15
p 1.0e-8
N 21,536
Meta-analysisLarge GWAS
European
About ZNRF3
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNRF3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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