rs1359790

This variant is located in the LOC105370275 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele A
OR 0.01
p 5.0e-102
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

type 2 diabetes mellitus

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)
Allele G
OR 1.09
p 2.0e-31
N 898,130
Large GWAS
European
Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)
Allele G
OR 0.08
p 3.0e-23
N 659,316
Large GWAS
multi-ancestry
Zhao W et al. “Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.” Nature Genetics 49(10):1450-1457 (2017)
Allele G
OR 0.08
p 8.0e-12
N 183,651
Large GWAS
multi-ancestry
Morris AP et al. “Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes” Nature Genetics (2012)
Allele G
OR 1.08
p 1.0e-8
N 69,033
Large GWAS
multi-ancestry
Flannick J et al. “Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.” Nature 570(7759):71-76 (2019)
Allele G
OR 1.12
p 2.0e-8
N 35,912
Large GWAS
multi-ancestry
Shu XO et al. “Identification of new genetic risk variants for type 2 diabetes.” Plos Genetics 6(9):e1001127 (2010)
Allele G
OR 1.15
p 6.0e-9
N 2,729
Large GWAS
multi-ancestry

Drugs used in diabetes use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.08
p 1.0e-21
N 484,639
Large GWAS
multi-ancestry
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele A
OR 0.10
p 1.0e-15
N 305,913
Major Consortium StudyLarge GWAS
European

HbA1c measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 5.0e-19
N 394,642
Large GWAS
European

type 2 diabetes mellitus, COVID-19

Guo H et al. “Identifying shared genetic loci between coronavirus disease 2019 and cardiovascular diseases based on cross-trait meta-analysis.” Frontiers in Microbiology 13:993933 (2022)
Allele G
OR 0.92
p 4.0e-9
N 166,789
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population
AssociationN=11,530Imamura M. et al.(2011)· Diabetologia

This replication study in 11,530 Japanese individuals (8,552 type 2 diabetes cases, 2,978 controls) confirmed that rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 are significantly associated with susceptibility to type 2 diabetes, with ORs of 1.15-1.17 and 1.12-1.14 respectively. Meta-analysis with the original Chinese cohort further strengthened these associations across East Asian populations, while rs1436955 in C2CD4A/C2CD4B showed nominal association and rs10751301 in ODZ4 was not significant.

Traits studied:Type 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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