rs1385374
This is a regulatory region variant variant in the SLC15A4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
systemic lupus erythematosus
Khunsriraksakul C et al. “Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.” Nature Communications 14(1):668 (2023)
Allele A
OR 0.12
p 2.0e-22
N 718,496
Large GWAS
multi-ancestry
Han JW et al. “Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.” Nature Genetics 41(11):1234-7 (2009)
Allele A
OR 1.26
p 2.0e-11
N 2,252
Large GWAS
East Asian
About SLC15A4
Enables several functions, including L-histidine transmembrane transporter activity; peptide:proton symporter activity; and peptidoglycan transmembrane transporter activity. Involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of pattern recognition receptor signaling pathway. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SLC15A4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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