rs139053442
This variant is located in the ICAM1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
intercellular adhesion molecule 1 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 1.85
p 2.0e-184
N 47,745
Large GWAS
European
Jiang MZ et al. “Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.” Human Molecular Genetics 33(16):1429-1441 (2024)
Allele C
OR 0.54
p 9.0e-17
N 9,268
Major Consortium StudyLarge GWAS
multi-ancestry
▶ClinVar annotation
Uncertain Significance★☆☆☆
1 submitter1 publicationAbout ICAM1
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
View all ICAM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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