ICAM1

intercellular adhesion molecule 1

Summary

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

Known Variants63 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs5490	19:10,381,827	A/C	regulatory region variant	benign
rs11575071	19:10,382,844	C/G	intron variant	—
rs747111380	19:10,385,491	C/T	—	uncertain significance
rs771818150	19:10,385,503	G/A	—	uncertain significance
rs992809768	19:10,385,520	C/T	—	likely benign
rs548184831	19:10,385,535	G/A	—	likely benign
rs5491	19:10,385,540	A/T	missense variant	risk factor
rs1371251341	19:10,385,597	A/G	—	uncertain significance
rs542476616	19:10,385,665	G/C	—	uncertain significance
rs192568008	19:10,386,549	C/A	—	—
rs192199315	19:10,388,834	C/T	intron variant	—
rs5030394	19:10,389,149	G/A	intron variant	—
rs281432	19:10,390,658	C/G	intron variant	—
rs5030370	19:10,391,535	G/C	—	—
rs7258215	19:10,391,770	T/G	—	—
rs5030376	19:10,393,051	G/A	upstream gene variant	—
rs5030399	19:10,394,153	G/A	—	likely benign
rs1258137966	19:10,394,191	C/G	—	likely benign
rs768846633	19:10,394,225	C/T	—	uncertain significance
rs377028532	19:10,394,241	G/A	—	uncertain significance
rs201079272	19:10,394,267	G/A	—	uncertain significance
rs750824008	19:10,394,279	C/T	—	uncertain significance
rs769975581	19:10,394,324	G/T	—	uncertain significance
rs749083718	19:10,394,328	A/C	—	uncertain significance
rs759046761	19:10,394,340	C/T	—	uncertain significance
rs139263745	19:10,394,364	A/G	—	uncertain significance
rs1007384990	19:10,394,384	C/T	—	uncertain significance
rs139053442	19:10,394,396	G/C	—	uncertain significance
rs373913806	19:10,394,438	G/A	—	uncertain significance
rs537554894	19:10,394,439	C/T	—	uncertain significance
rs35956512	19:10,394,764	G/A	—	likely benign
rs2512344946	19:10,394,767	G/C	—	uncertain significance
rs769386131	19:10,394,774	G/A	—	uncertain significance
rs143689328	19:10,394,791	C/T	—	likely benign
rs1799969	19:10,394,792	G/A	missense variant	benign
rs5030381	19:10,394,908	C/T	—	benign
rs5494	19:10,394,917	C/T	—	benign
rs201771459	19:10,394,938	G/A	—	likely benign
rs764794802	19:10,395,090	C/A	—	uncertain significance
rs762664096	19:10,395,094	A/T	—	uncertain significance
rs368283911	19:10,395,125	A/T	—	uncertain significance
rs146134321	19:10,395,141	G/A	—	likely benign
rs13306429	19:10,395,248	C/T	—	benign
rs766445571	19:10,395,282	G/A	—	uncertain significance
rs5496	19:10,395,447	G/A	regulatory region variant	—
rs5497	19:10,395,468	G/A	—	benign
rs753646159	19:10,395,490	G/A	—	uncertain significance
rs41276880	19:10,395,502	G/A	—	benign
rs760839324	19:10,395,601	C/T	—	likely benign
rs150121537	19:10,395,650	C/T	—	likely benign
rs779121366	19:10,395,651	G/A	—	likely benign
rs5498	19:10,395,683	A/G	missense variant	benign
rs115766769	19:10,395,769	G/A	coding sequence variant	—
rs376045646	19:10,395,785	C/T	—	likely benign
rs369459423	19:10,395,793	C/T	—	uncertain significance
rs5030400	19:10,395,796	C/T	—	conflicting classifications of pathogenicity
rs1480508060	19:10,395,799	T/C	—	uncertain significance
rs775418785	19:10,395,832	G/A	—	uncertain significance
rs1225105373	19:10,395,910	C/T	—	uncertain significance
rs189699084	19:10,396,692	C/T	coding sequence variant	—
rs75407602	19:10,397,230	C/G	coding sequence variant	—
rs281437	19:10,397,238	C/T	coding sequence variant	—
rs3093030	19:10,397,403	C/T	coding sequence variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.