rs3093030

This is a coding sequence variant variant in the ICAM1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

adhesion molecule measurement, ICAM-1 measurement

Barbalic M et al. “Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.” Human Molecular Genetics 19(9):1863-72 (2010)
Allele T
OR 4.15
p 4.0e-23
N 9,813
Large GWAS
European
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Research that mentions this SNP (2)

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Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment?
Meta-analysisN=434Victor M. Salinas-Torres et al.(2018)· Pediatric Surgery International

This systematic review analyzed genetic associations with gastroschisis from 1980-2017, identifying 14 SNPs from 10 genes associated with crude risk and 30 SNPs from 14 genes with stratified risk. Four SNPs showed significant associations: rs4961 (ADD1, p=0.023), rs5443 (GNB3, p=0.002), rs1042713 (ADRB2, p=0.007), and rs1042714 (ADRB2, p=0.006). The findings suggest genetic susceptibility in gastroschisis is not restricted to gene-environment interactions, with blood pressure regulation genes playing a significant role in vascular disruption pathogenesis.

Traits studied:Gastroschisis
PubMedDOIMetascience Observatory
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ICAM gene cluster SNPs and prostate cancer risk in African Americans
AssociationN=677Hankui Chen et al.(2006)· Human Genetics

A case-control study in African American men (286 cases, 391 controls) confirmed that ICAM1 SNPs -9A/C (rs5490, OR=2.5) and K469E (rs5498, OR=1.8) are associated with prostate cancer risk in familial disease. A common ICAM haplotype containing the -9A/C variant was significantly associated with prostate cancer (P=0.03), particularly in men with family history. Unlike previous findings in European populations, ICAM5 SNPs were not associated with prostate cancer in African Americans.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

About ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

View all ICAM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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