rs75407602

This is a coding sequence variant variant in the ICAM1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intercellular adhesion molecule 5 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele T

OR —

β 1.030

p 8.0e-86

N 3,301

Large GWAS

European

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele T

OR 1.14

p 2.0e-26

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

View all ICAM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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