rs5490

This is a regulatory region variant variant in the ICAM1 gene.

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ClinVar annotation

Benign
1 submitter

ICAM1-related disorder

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Research that mentions this SNP (1)

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ICAM gene cluster SNPs and prostate cancer risk in African Americans
AssociationN=677Hankui Chen et al.(2006)· Human Genetics

A case-control study in African American men (286 cases, 391 controls) confirmed that ICAM1 SNPs -9A/C (rs5490, OR=2.5) and K469E (rs5498, OR=1.8) are associated with prostate cancer risk in familial disease. A common ICAM haplotype containing the -9A/C variant was significantly associated with prostate cancer (P=0.03), particularly in men with family history. Unlike previous findings in European populations, ICAM5 SNPs were not associated with prostate cancer in African Americans.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

About ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

View all ICAM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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