rs5498

This is a variant in the ICAM1 gene that changes a lysine to an glutamate.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intercellular adhesion molecule 1 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 1.19

p —

N 10,708

Large GWAS

European

Jiang MZ et al. “Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.” Human Molecular Genetics 33(16):1429-1441 (2024)

Allele A

OR 0.05

p 3.0e-37

N 9,268

Major Consortium StudyLarge GWAS

multi-ancestry

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele A

OR —

β 1.200

p —

N 3,301

Large GWAS

European

protein measurement

Western D et al. “Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.” Nature Genetics 56(12):2672-2684 (2024)

Allele G

OR 1.14

p —

N 3,506

Large GWAS

European

ICAM-1 measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele G

OR 1.28

p 4.0e-303

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

Paré G et al. “Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.” Plos Genetics 7(4):e1001374 (2011)

Allele G

OR 13.80

p 6.0e-89

N 22,435

Large GWAS

European

Paré G et al. “Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.” Plos Genetics 4(7):e1000118 (2008)

Allele G

OR 13.22

p 5.0e-25

N 4,570

Large GWAS

European

Suhre K et al. “Connecting genetic risk to disease end points through the human blood plasma proteome.” Nature Communications 8:14357 (2017)

Allele G

OR 1.22

p 8.0e-267

N 997

Small GWAS

multi-ancestry

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele G

OR 1.26

p 5.0e-64

N 466

Small GWAS

African American or Afro-Caribbean

intercellular adhesion molecule 5 measurement

Suhre K et al. “Connecting genetic risk to disease end points through the human blood plasma proteome.” Nature Communications 8:14357 (2017)

Allele G

OR 0.51

p 2.0e-32

N 997

Small GWAS

multi-ancestry

neutrophil-to-lymphocyte ratio

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 4.0e-23

N 234,502

Large GWAS

European

diastolic blood pressure

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.01

p 7.0e-10

N 928,679

Large GWAS

multi-ancestry

lymphocyte count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR —

p 1.0e-105

N 643,370

Large GWAS

multi-ancestry

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.03

p 1.0e-50

N 408,112

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.04

p 1.0e-77

N 394,642

Large GWAS

European

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele G

OR —

p 3.0e-32

N 234,778

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.04

p 7.0e-30

N 171,643

Large GWAS

European

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ClinVar annotation

Benign

1 submitter

ICAM1-related disorder

View on ClinVar →

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Research that mentions this SNP (2)

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Genome‐wide association studies of cerebral white matter lesion burden

Meta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology

Genome-wide meta-analysis of 9,361 Europeans identified six genome-wide significant SNPs on chromosome 17q25 associated with white matter hyperintensity (WMH) burden. The most significant SNP, rs3744028 (P = 4.0×10⁻⁹ discovery, P = 1.3×10⁻⁷ replication, P = 4.0×10⁻¹⁵ combined), and rs1055129 were replicated in 3,024 additional individuals. Risk alleles increased WMH burden by 4-8% of mean burden.

Traits studied:Cerebral white matter lesionsWhite matter hyperintensities (WMH) burden

PubMed DOI Metascience Observatory

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ICAM gene cluster SNPs and prostate cancer risk in African Americans

AssociationN=677Hankui Chen et al.(2006)· Human Genetics

A case-control study in African American men (286 cases, 391 controls) confirmed that ICAM1 SNPs -9A/C (rs5490, OR=2.5) and K469E (rs5498, OR=1.8) are associated with prostate cancer risk in familial disease. A common ICAM haplotype containing the -9A/C variant was significantly associated with prostate cancer (P=0.03), particularly in men with family history. Unlike previous findings in European populations, ICAM5 SNPs were not associated with prostate cancer in African Americans.

Traits studied:Prostate cancer

PubMed DOI Metascience Observatory

About ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

rs5498

GWAS Catalog Trait Associations (7)

intercellular adhesion molecule 1 measurement

protein measurement

ICAM-1 measurement

intercellular adhesion molecule 5 measurement

neutrophil-to-lymphocyte ratio

diastolic blood pressure

lymphocyte count

ClinVar annotation

Research that mentions this SNP (2)

About ICAM1

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