rs140104536
This variant is located in the VIT gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
vitrin measurement
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele C
OR 1.01
p 2.0e-70
N 10,708
Large GWAS
European
Allele C
OR —
β 1.300
p 1.0e-31
N 3,301
Large GWAS
European
osteoarthritis, hip, total hip arthroplasty
Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)
Allele C
OR 0.83
p 1.0e-8
N 1,031,046
Large GWAS
multi-ancestry
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout VIT
This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. [provided by RefSeq, Jun 2016]
View all VIT variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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