rs1405655

This variant is located in the NR1H2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

COVID-19

Diz-de Almeida S et al. “Novel risk loci for COVID-19 hospitalization among admixed American populations.” Elife 13 (2024)
Allele T
OR 0.08
p 2.0e-19
N 73,303
Large GWAS
multi-ancestry
Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)
Allele T
OR 0.93
p 6.0e-16
N 2,974,917
Meta-analysisLarge GWAS
multi-ancestry
“A first update on mapping the human genetic architecture of COVID-19.” Nature 608(7921):E1-E10 (2022)
Allele T
OR 1.07
p 5.0e-11
N 2,861,299
Large GWAS
multi-ancestry

respiratory failure, COVID-19

Degenhardt F et al. “Detailed stratified GWAS analysis for severe COVID-19 in four European populations.” Human Molecular Genetics 31(23):3945-3966 (2022)
Allele C
OR 1.09
p 3.0e-8
N 2,641,520
Large GWAS
European, NR
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Research that mentions this SNP (1)

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Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes
AssociationN=1,574Caroline Ketterer et al.(2011)· Journal of Molecular Medicine

In 1,574 subjects of European ancestry at high risk for type 2 diabetes, genetic variation in the NR1H2 gene (encoding liver X receptor β) was associated with impaired insulin secretion. The SNP rs2248949 showed significant association with insulin secretion during IVGTT (p=0.007) in a dominant model, with minor allele carriers showing 26% reduced insulin secretion. NR1H2 rs1405655 was also associated with first-phase insulin secretion (p=0.003), and NR1H3 rs11039149 associated with proinsulin conversion to insulin.

Traits studied:Fasting glucoseFirst-phase insulin secretionInsulin secretionInsulin sensitivityProinsulin conversionType 2 diabetes
PubMedDOIMetascience Observatory

About NR1H2

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

View all NR1H2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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