rs1422192
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
irritability measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.95
p 4.0e-12
N 366,726
Large GWAS
European
social interaction measurement
Day FR et al. “Elucidating the genetic basis of social interaction and isolation.” Nature Communications 9(1):2457 (2018)
Allele G
OR 0.01
p 4.0e-12
N 452,302
Large GWAS
European
neuroticism measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.17
p 7.0e-10
N 380,506
Large GWAS
European
mood disorder, major depressive disorder
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 0.02
p 1.0e-9
N 357,957
Meta-analysisLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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