rs143035740

This variant is located in the PRR12 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total blood protein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.14
p 3.0e-60
N 394,642
Large GWAS
European
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ClinVar annotation

Benign★★★☆
4 submitters2 publications

not provided; Uterine corpus endometrial carcinoma; Uveal melanoma; Colon adenocarcinoma; Colorectal cancer; Thyroid cancer, nonmedullary, 1; Cervical cancer; Familial cancer of breast; Ovarian serous cystadenocarcinoma; Cholangiocarcinoma

View on ClinVar →

About PRR12

This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016]

View all PRR12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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