rs1438673

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma, Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele C
OR 1.09
p 7.0e-62
N 346,545
Major Consortium StudyLarge GWAS
European

Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele C
OR 1.10
p 2.0e-58
N 323,807
Major Consortium StudyLarge GWAS
European

allergic rhinitis

Waage J et al. “Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.” Nature Genetics 50(8):1072-1080 (2018)
Allele C
OR 1.08
p 3.0e-26
N 212,120
Large GWAS
multi-ancestry

allergic disease

Hinds DA et al. “A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.” Nature Genetics 45(8):907-11 (2013)
Allele C
OR 0.11
p 2.0e-20
N 53,862
Meta-analysisLarge GWAS
European

asthma

Shrine N et al. “Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.” The Lancet. Respiratory Medicine 7(1):20-34 (2019)
Allele C
OR 1.12
p 3.0e-13
N 30,810
Large GWAS
European

asthma, seasonal allergic rhinitis

Ferreira MA et al. “Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.” The Journal of Allergy and Clinical Immunology 133(6):1564-71 (2014)
Allele C
OR 1.16
p 3.0e-11
N 20,776
Large GWAS
European

seasonal allergic rhinitis

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.06
p 1.0e-8
N 647,637
Large GWAS
multi-ancestry

eosinophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 1.0e-36
N 447,366
Major Consortium StudyLarge GWAS
multi-ancestry

eosinophilic esophagitis

Chang X et al. “A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci.” The Journal of Allergy and Clinical Immunology 149(3):988-998 (2022)
Allele C
OR 1.43
p 1.0e-13
N 7,836
Meta-analysis
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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