rs144504271
This is a intron variant variant in the HECTD4 gene.
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
serum gamma-glutamyl transferase measurement
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.24
p —
N 153,950
Large GWAS
East Asian
alcohol consumption quality
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele A
OR 1.32
p 5.0e-89
N 8,252
Large GWAS
East Asian
Flushing
Inoue Y et al. “Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome-wide association study.” Experimental Dermatology 30(12):1787-1793 (2021)
Allele A
OR 0.41
p 1.0e-24
N 1,108
Large GWAS
East Asian
glomerular filtration rate
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele A
OR 0.84
p 1.0e-19
N 58,406
Large GWAS
East Asian
blood urea nitrogen amount
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele A
OR 0.02
p 1.0e-18
N 58,406
Large GWAS
East Asian
cups of coffee per day measurement
Nakagawa-Senda H et al. “A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study.” Scientific Reports 8(1):1493 (2018)
Allele A
OR 0.19
p 2.0e-15
N 11,261
Large GWAS
East Asian
carbohydrate intake measurement
Nakamura Y et al. “A genome-wide association study on adherence to low-carbohydrate diets in Japanese.” European Journal of Clinical Nutrition 76(8):1103-1110 (2022)
Allele A
OR —
p 4.0e-15
N 14,076
Large GWAS
East Asian
forced expiratory volume, body mass index
Zhu Z et al. “A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity.” The European Respiratory Journal 58(4) (2021)
Allele G
OR —
p 2.0e-12
N 100,285
Large GWAS
multi-ancestry
low density lipoprotein cholesterol measurement
Lee SB et al. “Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.” Biomedicines 10(7) (2022)
Allele A
OR 1.61
p 2.0e-10
N 58,701
Large GWAS
East Asian
uric acid measurement
Cho SK et al. “Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals.” Scientific Reports 10(1):9179 (2020)
Allele A
OR 0.15
p 1.0e-9
N 6,881
Large GWAS
East Asian
About HECTD4
Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all HECTD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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