rs1449544

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele C

OR 0.21

p 6.0e-33

N 1,028,980

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 1.0e-17

N 506,308

Large GWAS

multi-ancestry

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele C

OR 0.25

p 4.0e-24

N 459,777

Large GWAS

multi-ancestry

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele C

OR 0.20

p 3.0e-15

N 321,262

Large GWAS

multi-ancestry

systolic blood pressure

Allele C

OR 0.22

p 2.0e-20

N 1,028,980

Large GWAS

multi-ancestry

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele C

OR 0.22

p 4.0e-11

N 459,777

Large GWAS

multi-ancestry

aortic measurement

Pirruccello JP et al. “The Genetic Determinants of Aortic Distention.” Journal of the American College of Cardiology 81(14):1320-1335 (2023)

Allele A

OR 0.04

p 6.0e-12

N 33,907

Large GWAS

European, NR

This variant is in our database but has no known associations or PRS memberships yet.

rs1449544

GWAS Catalog Trait Associations (3)

pulse pressure measurement

systolic blood pressure

aortic measurement

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