rs145049847
This is a regulatory region variant variant in the SDR42E2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease, age at onset
Herold C et al. “Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.” Molecular Psychiatry 21(11):1608-1612 (2016)
Allele C
OR 5.77
p 8.0e-9
N 4,527
Large GWAS
European
About SDR42E2
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]
View all SDR42E2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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