rs148258173

This is a intergenic variant variant in the FANCB gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at menopause

Ruth KS et al. “Genetic insights into biological mechanisms governing human ovarian ageing.” Nature 596(7872):393-397 (2021)

Allele T

OR 0.20

p 4.0e-33

N 201,323

Large GWAS

multi-ancestry

About FANCB

This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016]

View all FANCB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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