rs149082597
This variant is located in the LRP4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele G
OR 0.14
p 2.0e-10
N 426,824
Large GWAS
European
▶ClinVar annotation
Conflicting Classifications
9 submitters4 publicationsnot provided; Sclerosteosis 2;Cenani-Lenz syndactyly syndrome;Congenital myasthenic syndrome 17; Cenani-Lenz syndactyly syndrome; LRP4-related disorder; Meniere disease
View on ClinVar →About LRP4
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
View all LRP4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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