rs1502492

This is a downstream gene variant variant in the NLGN1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 1.0e-21

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About NLGN1

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

View all NLGN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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