rs150962800
This variant is located in the FMN1 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
nevus count, cutaneous melanoma
Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)
Allele C
OR —
p 1.0e-18
N 477,725
Large GWAS
European
cutaneous melanoma
Liyanage UE et al. “Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma.” The Journal of Investigative Dermatology 142(6):1607-1616 (2022)
Allele C
OR 0.17
p 5.0e-14
N 380,287
Large GWAS
European
balding measurement
Yap CX et al. “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.” Nature Communications 9(1):5407 (2018)
Allele T
OR 0.07
p 1.0e-13
N 205,327
Large GWAS
European
aging rate
Roberts V et al. “Genome-Wide Association Study Identifies Genetic Associations with Perceived Age.” The Journal of Investigative Dermatology 140(12):2380-2385 (2020)
Allele C
OR 0.92
p 4.0e-9
N 423,992
Large GWAS
European
▶ClinVar annotation
About FMN1
This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
View all FMN1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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