rs151161986
This variant is located in the DNASE1L3 gene.
▶ClinVar annotation
not provided; Autosomal systemic lupus erythematosus type 16
View on ClinVar →▶Research that mentions this SNP (1)
▶Evidence for gene–gene epistatic interactions among susceptibility loci for systemic lupus erythematosusReviewHughes T. et al.(2012)· Arthritis & Rheumatism
A comprehensive review of genetic variants contributing to systemic lupus erythematosus (SLE), covering both polygenic (>100 susceptibility loci) and monogenic (1-10% of cases) contributions identified through NGS techniques. Key susceptibility genes include STAT4, BANK1, TNFAIP3, BLK, IRF5, ETS1, and TNIP1, with early-onset SLE showing greater genetic burden particularly in Black, Asian, and Hispanic ancestries.
About DNASE1L3
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
View all DNASE1L3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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