DNASE1L3
deoxyribonuclease 1L3
Summary
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Known Variants196 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs746100795 | 3:58,178,414 | C/A | — | uncertain significance |
| rs780196315 | 3:58,178,422 | G/A | — | uncertain significance |
| rs2471300937 | 3:58,178,429 | C/G | — | uncertain significance |
| rs2471300950 | 3:58,178,432 | T/C | — | likely benign |
| rs774817141 | 3:58,178,456 | T/A | — | uncertain significance |
| rs970045878 | 3:58,178,472 | A/G | — | uncertain significance |
| rs151161986 | 3:58,178,478 | C/T | — | uncertain significance |
| rs759238109 | 3:58,178,480 | T/C | — | likely benign |
| rs764180604 | 3:58,178,517 | C/G | — | uncertain significance |
| rs1459154419 | 3:58,178,519 | G/A | — | likely benign |
| rs113005222 | 3:58,178,529 | G/C | — | uncertain significance |
| rs750128475 | 3:58,178,533 | A/G | — | uncertain significance |
| rs2471301072 | 3:58,178,536 | A/T | — | likely benign |
| rs2471301076 | 3:58,178,539 | A/C | — | likely benign |
| rs1433369342 | 3:58,178,545 | G/C | — | likely benign |
| rs2107365164 | 3:58,178,548 | A/G | — | likely benign |
| rs1313569916 | 3:58,178,550 | G/C | — | uncertain significance |
| rs3732630 | 3:58,179,028 | T/C | — | benign |
| rs373633551 | 3:58,179,053 | C/G | — | likely benign |
| rs377465977 | 3:58,179,056 | G/A | — | likely benign |
| rs563541630 | 3:58,179,060 | G/T | — | likely benign |
| rs774002626 | 3:58,179,063 | A/T | — | likely benign |
| rs2097395289 | 3:58,179,066 | T/C | — | uncertain significance |
| rs2107365778 | 3:58,179,071 | T/C | — | uncertain significance |
| rs2107365783 | 3:58,179,073 | C/G | — | uncertain significance |
| rs146444966 | 3:58,179,089 | T/G | — | uncertain significance |
| rs138248740 | 3:58,179,094 | T/C | — | likely benign |
| rs1575494468 | 3:58,179,103 | G/T | — | uncertain significance |
| rs2097395318 | 3:58,179,126 | G/T | — | uncertain significance |
| rs778387758 | 3:58,179,141 | C/T | — | uncertain significance |
| rs76440799 | 3:58,179,142 | G/C | — | uncertain significance |
| rs2471301957 | 3:58,179,149 | T/C | — | uncertain significance |
| rs1362901133 | 3:58,179,156 | T/C | — | uncertain significance |
| rs1326080052 | 3:58,179,160 | C/T | — | likely benign |
| rs747698984 | 3:58,179,162 | C/G | — | uncertain significance |
| rs186823038 | 3:58,179,169 | G/A | — | likely benign |
| rs770832574 | 3:58,179,176 | G/A | — | likely benign |
| rs2471302057 | 3:58,179,178 | G/A | — | likely benign |
| rs3856708 | 3:58,181,500 | A/T | — | — |
| rs756526411 | 3:58,183,530 | C/A | — | likely benign |
| rs747788809 | 3:58,183,538 | G/T | — | likely benign |
| rs771697274 | 3:58,183,544 | C/T | — | uncertain significance |
| rs1575496319 | 3:58,183,553 | A/G | — | likely benign |
| rs536813039 | 3:58,183,563 | T/C | — | uncertain significance |
| rs1277300116 | 3:58,183,568 | G/A | — | likely benign |
| rs745705886 | 3:58,183,580 | C/T | — | likely benign |
| rs769575190 | 3:58,183,581 | G/A | — | uncertain significance |
| rs369901098 | 3:58,183,591 | C/G | — | uncertain significance |
| rs181083454 | 3:58,183,598 | C/T | — | likely benign |
| rs768188569 | 3:58,183,601 | G/T | — | likely benign |
| rs2107370856 | 3:58,183,606 | G/A | — | likely benign |
| rs527809170 | 3:58,183,616 | C/T | — | likely benign |
| rs750960835 | 3:58,183,621 | G/C | — | uncertain significance |
| rs766863381 | 3:58,183,635 | C/T | — | uncertain significance |
| rs35677470 | 3:58,183,636 | G/A | missense variant | likely benign |
| rs777430061 | 3:58,183,651 | C/T | — | uncertain significance |
| rs1344904745 | 3:58,183,656 | T/C | — | uncertain significance |
| rs1366194393 | 3:58,183,661 | G/A | — | likely benign |
| rs745795646 | 3:58,183,664 | G/A | — | likely benign |
| rs758281617 | 3:58,183,668 | C/T | — | likely benign |
| rs775273181 | 3:58,183,672 | A/C | — | uncertain significance |
| rs200457209 | 3:58,183,675 | C/T | — | uncertain significance |
| rs148439707 | 3:58,183,676 | G/A | — | likely benign |
| rs2471306385 | 3:58,183,680 | T/C | — | pathogenic |
| rs1575496407 | 3:58,183,685 | G/A | — | likely benign |
| rs761268539 | 3:58,183,688 | A/G | — | likely benign |
| rs1313460433 | 3:58,183,689 | C/G | — | uncertain significance |
| rs2107370990 | 3:58,183,709 | A/G | — | likely benign |
| rs2107373805 | 3:58,186,712 | A/G | — | likely benign |
| rs373126531 | 3:58,186,716 | G/A | — | conflicting classifications of pathogenicity |
| rs777161573 | 3:58,186,718 | C/A | — | uncertain significance |
| rs3772985 | 3:58,186,719 | A/C | — | uncertain significance |
| rs61730077 | 3:58,186,727 | C/T | — | likely benign |
| rs1346555886 | 3:58,186,729 | C/T | — | uncertain significance |
| rs2107373870 | 3:58,186,733 | C/T | — | likely pathogenic |
| rs3772986 | 3:58,186,737 | C/A | — | uncertain significance |
| rs2471309434 | 3:58,186,745 | C/T | — | likely benign |
| rs146622951 | 3:58,186,748 | G/C | — | uncertain significance |
| rs138720416 | 3:58,186,751 | C/G | — | likely benign |
| rs761070297 | 3:58,186,754 | G/A | — | likely benign |
| rs770137098 | 3:58,186,766 | C/G | — | uncertain significance |
| rs2471309468 | 3:58,186,768 | A/G | — | likely benign |
| rs149185668 | 3:58,186,769 | C/T | — | likely benign |
| rs919216955 | 3:58,186,774 | C/G | — | uncertain significance |
| rs142361820 | 3:58,186,775 | G/C | — | likely benign |
| rs375425278 | 3:58,186,787 | G/C | — | likely benign |
| rs147219402 | 3:58,186,804 | T/G | — | uncertain significance |
| rs2097400262 | 3:58,186,805 | G/A | — | likely benign |
| rs778204609 | 3:58,186,819 | T/C | — | likely benign |
| rs146805633 | 3:58,186,822 | C/T | — | uncertain significance |
| rs757366118 | 3:58,186,823 | G/A | — | likely benign |
| rs370862010 | 3:58,186,826 | G/A | — | likely benign |
| rs201928908 | 3:58,186,833 | A/G | — | uncertain significance |
| rs1201712392 | 3:58,186,844 | A/G | — | likely benign |
| rs1176139659 | 3:58,186,849 | A/G | — | likely benign |
| rs2471309671 | 3:58,186,851 | A/G | — | likely benign |
| rs2471309675 | 3:58,186,855 | G/T | — | likely benign |
| rs752963121 | 3:58,186,856 | C/T | — | likely benign |
| rs4234389 | 3:58,186,911 | G/A | — | benign |
| rs770360003 | 3:58,190,480 | C/G | — | likely benign |
Showing 100 of 196 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.