Trait
SNPs associated with Systemic Scleroderma
53 genetic variants across 19 genes have been associated with Systemic Scleroderma in published research. Key genes include AHNAK2, BLK, CSK.
Associated variants53 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs7574865 | STAT4 | GWAS association (p=2.0e-13) | Meta-analysis |
| rs2736346 | BLK | GWAS association (p=2.0e-12) | Meta-analysis |
| rs4731532 | — | GWAS association (p=2.0e-12) | Meta-analysis |
| rs3894194 | GSDMA | GWAS association (p=1.0e-10) | Meta-analysis |
| rs4134466 | — | GWAS association (p=7.0e-10) | Meta-analysis |
| rs1422673 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs35677470 | DNASE1L3 | GWAS association (p=4.0e-31) | Meta-analysis |
| rs6457617 | HLA-DQB1 | GWAS association (p=2.0e-37) | Large GWAS |
| rs4853458 | STAT4 | GWAS association (p=2.0e-35) | Large GWAS |
| rs2736340 | — | GWAS association (p=1.0e-26) | Large GWAS |
| rs3821236 | STAT4 | GWAS association (p=3.0e-09) | Large GWAS |
| rs36073657 | TNPO3 | GWAS association (p=3.0e-21) | Large GWAS |
| rs11889341 | STAT4 | GWAS association (p=3.0e-20) | Large GWAS |
| rs11117420 | — | GWAS association (p=1.0e-17) | Large GWAS |
| rs4728142 | — | GWAS association (p=2.0e-15) | Large GWAS |
| rs1378942 | CSK | GWAS association (p=9.0e-15) | Large GWAS |
| rs5029937 | TNFAIP3 | GWAS association (p=2.0e-13) | Large GWAS |
| rs10488631 | IRF5 | GWAS association (p=2.0e-13) | Large GWAS |
| rs9884090 | — | GWAS association (p=6.0e-13) | Large GWAS |
| rs3792783 | TNIP1 | GWAS association (p=2.0e-12) | Large GWAS |
| rs230534 | NFKB1 | GWAS association (p=4.0e-12) | Large GWAS |
| rs844663 | — | GWAS association (p=5.0e-12) | Large GWAS |
| rs10912594 | TNFSF4 | GWAS association (p=6.0e-12) | Large GWAS |
| rs77583790 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs76285340 | FLG-AS1 | GWAS association (p=2.0e-11) | Large GWAS |
| rs11851053 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs2819422 | AHNAK2 | GWAS association (p=3.0e-11) | Large GWAS |
| rs11724804 | — | GWAS association (p=5.0e-11) | Large GWAS |
| rs6697139 | — | GWAS association (p=5.0e-11) | Large GWAS |
| rs548234 | — | GWAS association (p=8.0e-11) | Large GWAS |
| rs4076852 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs10892286 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs5029949 | TNFAIP3 | GWAS association (p=2.0e-10) | Large GWAS |
| rs2045526 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs7355798 | FLNB | GWAS association (p=3.0e-10) | Large GWAS |
| rs3790566 | — | GWAS association (p=4.0e-10) | Large GWAS |
| rs3130573 | PSORS1C1 | GWAS association (p=6.0e-10) | Large GWAS |
| rs589446 | IL12A-AS1 | GWAS association (p=8.0e-10) | Large GWAS |
| rs883770 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs45471499 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs7601754 | STAT4 | GWAS association (p=1.0e-09) | Large GWAS |
| rs2013112 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs633724 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs2233287 | TNIP1 | GWAS association (p=5.0e-09) | Large GWAS |
| rs16832798 | — | GWAS association (p=5.0e-09) | Large GWAS |
| rs10484921 | ESR1 | GWAS association (p=8.0e-09) | Large GWAS |
| rs1005714 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs17340646 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs2305743 | IL12RB1 | GWAS association (p=2.0e-08) | Large GWAS |
| rs398390 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs9074 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs9373839 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs4317244 | — | GWAS association (p=4.0e-08) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.