TNFSF4

TNF superfamily member 4

Summary

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Known Variants43 total

rsidPosition (GRCh37)AllelesClassClinVar
rs49163121:173,146,357G/Aupstream gene variant
rs40903911:173,147,090C/Tupstream gene variant
rs101274951:173,148,671A/Cdownstream gene variant
rs75142291:173,154,304G/T3 prime UTR variant
rs618263451:173,154,354A/C3 prime UTR variant
rs25257280801:173,155,708C/Tuncertain significance
rs3776558341:173,155,729G/Alikely benign
rs5666293551:173,155,822G/Cuncertain significance
rs1462618311:173,155,860C/Tuncertain significance
rs7455411821:173,155,945C/Tuncertain significance
rs38619501:173,156,292T/Cintron variant
rs1418377531:173,157,676G/Abenign
rs1476755281:173,157,698C/Tlikely benign
rs75181291:173,163,568A/Gintron variant
rs12343131:173,166,247A/Gintron variant
rs133431071:173,168,321A/Gintron variant
rs109125641:173,170,618C/Tintron variant
rs168456071:173,173,617G/Aintron variant
rs38506411:173,175,832A/Gintron variant
rs454542931:173,177,236C/Tupstream gene variant
rs12343141:173,177,392C/A
rs12343151:173,178,463C/A
rs12343171:173,187,775C/Tintergenic variant
rs22059601:173,191,475G/A
rs8446441:173,209,495A/Cintergenic variant
rs1172784801:173,210,789A/Gregulatory region variant
rs120399041:173,212,273C/G
rs121377471:173,213,790C/T
rs8446481:173,223,863G/Aintergenic variant
rs7048401:173,226,195T/Gintergenic variant
rs109125801:173,256,550A/Gintergenic variant
rs1445516161:173,262,228A/Gintergenic variant
rs49163211:173,284,199G/A
rs13420381:173,301,516G/C
rs66814821:173,306,646G/Aintergenic variant
rs107982691:173,309,713A/Gintergenic variant
rs109125941:173,318,664G/Cupstream gene variant
rs24223451:173,337,747G/Aupstream gene variant
rs107530741:173,346,343C/G
rs21053251:173,349,725A/T
rs1858354061:173,370,858A/Gintergenic variant
rs5617081651:173,378,833A/C
rs5444140251:173,400,283G/A

Gene information from NCBI Gene. Variant classifications from ClinVar.