rs3861950
This is a intron variant variant in the TNFSF4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
serum IgA amount
▶Research that mentions this SNP (1)
▶A genome-wide association study of breast cancer in women of African ancestryAssociationN=21,921Chen F. et al.(2013)· Human Genetics
Genome-wide association study of breast cancer in 3,153 African American cases and 2,831 controls, with replication in 3,607 cases and 11,330 controls of African ancestry. Two novel susceptibility loci reached statistical significance: rs4322600 at 14q31 (OR=1.18, p=4.3×10⁻⁶) and rs10510333 at 3p26 (OR=1.15, p=1.5×10⁻⁵). These variants represent novel risk loci not previously identified in other populations.
About TNFSF4
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
View all TNFSF4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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