rs7518129

This is a intron variant variant in the TNFSF4 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)

Allele G

OR 1.11

p 2.0e-11

N 327,670

Large GWAS

European

asthma

Allele G

OR 0.85

p 5.0e-9

N 37,846

Large GWAS

European

About TNFSF4

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

View all TNFSF4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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