rs2422345
This is a upstream gene variant variant in the TNFSF4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus
Acosta-Herrera M et al. “Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.” Annals of the Rheumatic Diseases 78(3):311-319 (2019)
Allele A
OR 1.11
p 3.0e-8
N 31,408
Meta-analysisLarge GWAS
European
About TNFSF4
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
View all TNFSF4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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