rs3850641
This is a intron variant variant in the TNFSF4 gene.
▶Research that mentions this SNP (1)
▶Genetic variants of TNFSF4 and risk for carotid artery disease and strokeAssociationN=2,752Olofsson PS et al.(2009)· Journal of Molecular Medicine
Olofsson et al. investigated whether SNP rs3850641 in TNFSF4, previously associated with myocardial infarction in women, was associated with carotid artery disease and ischemic stroke. While they demonstrated that TNFSF4 is expressed in human atherosclerotic lesions and upregulated by TNFα in endothelial cells, their case-control analysis found NO significant association between the minor allele and risk of ischemic stroke (OR 0.89, p=0.23) or carotid artery stenosis (OR 0.73, p=0.23).
About TNFSF4
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
View all TNFSF4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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