TNFAIP3

TNF alpha induced protein 3

Summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

Known Variants458 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs59693083	6:138,186,532	A/G	regulatory region variant	—
rs583522	6:138,189,884	C/A	—	—
rs5029928	6:138,189,942	C/T	upstream gene variant	—
rs2114457420	6:138,192,380	C/A	—	uncertain significance
rs1461832435	6:138,192,386	C/T	—	likely pathogenic
rs1582884850	6:138,192,387	A/G	—	uncertain significance
rs138988092	6:138,192,398	T/C	—	likely benign
rs1178250150	6:138,192,400	G/A	—	likely benign
rs1470990172	6:138,192,401	A/G	—	uncertain significance
rs1414718116	6:138,192,410	C/T	—	uncertain significance
rs1302093455	6:138,192,424	G/C	—	uncertain significance
rs149162594	6:138,192,426	T/C	—	uncertain significance
rs183283680	6:138,192,427	A/T	—	likely benign
rs199876928	6:138,192,429	G/A	—	uncertain significance
rs757112036	6:138,192,438	C/T	—	conflicting classifications of pathogenicity
rs1187264052	6:138,192,451	T/A	—	likely benign
rs758096571	6:138,192,452	T/C	—	uncertain significance
rs770145346	6:138,192,470	A/C	—	uncertain significance
rs2482708176	6:138,192,477	A/G	—	uncertain significance
rs370854824	6:138,192,489	C/G	—	likely benign
rs1173941971	6:138,192,497	C/T	—	pathogenic
rs1422470027	6:138,192,498	G/A	—	likely benign
rs774689592	6:138,192,505	A/G	—	likely benign
rs2482708655	6:138,192,519	G/C	—	uncertain significance
rs2114459340	6:138,192,522	C/G	—	uncertain significance
rs1776055887	6:138,192,527	C/T	—	likely pathogenic
rs529257107	6:138,192,536	C/A	—	uncertain significance
rs772369780	6:138,192,538	T/G	—	likely benign
rs970781981	6:138,192,545	C/T	—	uncertain significance
rs775364265	6:138,192,546	G/A	—	uncertain significance
rs1776057762	6:138,192,551	A/G	—	uncertain significance
rs1344440576	6:138,192,557	C/G	—	uncertain significance
rs761575322	6:138,192,563	G/T	—	uncertain significance
rs1270108606	6:138,192,566	C/T	—	uncertain significance
rs548932103	6:138,192,571	C/G	—	conflicting classifications of pathogenicity
rs2482709603	6:138,192,582	T/C	—	uncertain significance
rs1391482330	6:138,192,585	A/C	—	uncertain significance
rs1776060477	6:138,192,591	C/T	—	uncertain significance
rs148028402	6:138,192,601	C/G	—	uncertain significance
rs2482709950	6:138,192,603	A/G	—	uncertain significance
rs779379836	6:138,192,613	C/T	—	likely benign
rs1363086770	6:138,192,624	G/A	—	uncertain significance
rs747030410	6:138,192,632	C/T	—	uncertain significance
rs1422450549	6:138,192,633	G/A	—	uncertain significance
rs2114460904	6:138,192,634	G/A	—	likely benign
rs1253044936	6:138,192,643	G/C	—	likely benign
rs776714084	6:138,192,645	C/T	—	uncertain significance
rs142122102	6:138,192,646	G/A	—	likely benign
rs1272733096	6:138,192,649	G/A	—	likely benign
rs376435384	6:138,192,655	G/A	—	likely benign
rs146004919	6:138,192,658	C/T	—	conflicting classifications of pathogenicity
rs370813134	6:138,192,667	T/C	—	likely benign
rs367719917	6:138,192,670	T/C	—	likely benign
rs719149	6:138,192,745	G/A	regulatory region variant	benign
rs719150	6:138,192,761	A/G	—	benign
rs5029937	6:138,195,151	G/T	regulatory region variant	—
rs3799491	6:138,195,392	G/A	regulatory region variant	—
rs598493	6:138,195,402	T/C	regulatory region variant	—
rs5029939	6:138,195,723	C/G	regulatory region variant	—
rs769709964	6:138,195,965	C/G	—	likely benign
rs377482653	6:138,195,967	C/T	—	likely benign
rs2114477149	6:138,195,977	C/G	—	benign
rs368218194	6:138,195,986	C/T	—	likely benign
rs1409953541	6:138,195,987	G/A	—	uncertain significance
rs146534657	6:138,195,991	A/G	—	likely benign
rs766242605	6:138,195,999	A/T	—	uncertain significance
rs376205580	6:138,196,008	A/G	—	likely benign
rs150717698	6:138,196,029	G/A	—	uncertain significance
rs1258341126	6:138,196,047	G/A	—	likely benign
rs139060168	6:138,196,052	G/C	—	likely benign
rs2114477857	6:138,196,058	G/T	—	uncertain significance
rs5029941	6:138,196,060	C/T	—	conflicting classifications of pathogenicity
rs2230926	6:138,196,066	T/G	missense variant	likely benign
rs183020993	6:138,196,072	C/T	—	uncertain significance
rs531220369	6:138,196,073	G/A	—	likely benign
rs202005030	6:138,196,076	C/G	—	likely benign
rs200740561	6:138,196,092	C/T	—	benign
rs1405321250	6:138,196,093	G/A	—	uncertain significance
rs760241707	6:138,196,106	C/T	—	likely benign
rs1324560863	6:138,196,107	C/T	—	uncertain significance
rs765554483	6:138,196,108	G/A	—	uncertain significance
rs2482727350	6:138,196,111	G/A	—	likely pathogenic
rs2114478741	6:138,196,126	T/A	—	uncertain significance
rs2114478790	6:138,196,134	C/T	—	pathogenic
rs867703039	6:138,196,135	A/G	—	uncertain significance
rs750716064	6:138,196,150	C/G	—	uncertain significance
rs140424499	6:138,196,151	G/A	—	likely benign
rs1431526097	6:138,196,153	G/T	—	uncertain significance
rs1390830383	6:138,196,162	A/G	—	uncertain significance
rs587778710	6:138,196,170	C/T	—	not provided
rs144788826	6:138,196,171	G/A	—	uncertain significance
rs2114479182	6:138,196,178	T/A	—	uncertain significance
rs2482728080	6:138,196,181	T/C	—	likely benign
rs756348119	6:138,196,182	T/C	—	likely benign
rs376559304	6:138,196,183	C/A	—	likely benign
rs192376488	6:138,196,187	C/T	—	benign
rs751476356	6:138,196,188	T/C	—	likely benign
rs2114479294	6:138,196,189	A/G	—	likely benign
rs2482728206	6:138,196,190	A/G	—	likely benign
rs1307038905	6:138,196,192	T/C	—	likely benign

Showing 100 of 458 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.