rs5029928
This is a upstream gene variant variant in the TNFAIP3 gene.
▶Research that mentions this SNP (1)
▶TNFAIP3 gene polymorphisms confer risk for Behcet’s disease in a Chinese Han populationAssociationN=2,137Hong Li et al.(2013)· Human Genetics
This candidate gene association study examined five TNFAIP3 SNPs (rs10499194, rs610604, rs7753873, rs5029928, rs9494885) in 722 Chinese Han Behcet's disease patients and 1,415 controls. The strongest association was rs9494885 with BD (TC genotype OR=2.03, p=1.83×10⁻¹⁰), while rs10499194 and rs7753873 showed weaker associations. The rs9494885 TT genotype was protective (OR=0.50, p=1.23×10⁻¹⁰).
About TNFAIP3
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
View all TNFAIP3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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