rs1519480

This is a downstream gene variant variant in the BDNF-AS gene.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 1.0e-39
N 2,669,029
Large GWAS
European

triglyceride measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.01
p 3.0e-16
N 1,320,016
Large GWAS
European
Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)
Allele T
OR 0.02
p 7.0e-13
N 297,626
Major Consortium StudyLarge GWAS
multi-ancestry

body mass index

Gong J et al. “Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.” International Journal of Obesity (2005) 42(3):384-390 (2018)
Allele A
OR 0.01
p 2.0e-11
N 102,514
Large GWAS
multi-ancestry

high density lipoprotein cholesterol measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.02
p 1.0e-11
N 578,125
Major Consortium StudyLarge GWAS
multi-ancestry
Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)
Allele C
OR 0.01
p 6.0e-10
N 297,626
Major Consortium StudyLarge GWAS
multi-ancestry
▶

Research that mentions this SNP (1)

▶
No association of brain‐derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese
ReviewTetsuya Ando et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This literature review examines the BDNF Val66Met polymorphism (rs6265) and its association with body weight fluctuations in psychiatric patients. The authors review evidence linking the Val66Met variant to weight changes across multiple psychiatric conditions including schizophrenia, eating disorders, bipolar disorder, major depressive disorder, OCD, and PTSD. The paper proposes the BDNF Val66Met polymorphism as a potential biomarker for monitoring body weight changes in psychiatric patients, noting that Met/Met genotype carriers show greater BMI increases particularly in schizophrenia and bipolar disorder.

Traits studied:Alzheimer's diseaseAnorexia nervosaBMIBipolar disorderBladder cancerBody weightBreast cancerBulimia nervosaCancerCardiovascular diseaseCoronary artery diseaseEating disordersGeneralized anxiety disorderMajor depressive disorderMetabolic syndromeMultiple sclerosisObesityObsessive-compulsive disorderParkinson's diseasePost-traumatic stress disorderSchizophreniaSubstance-related disordersType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…