rs153109

This is a regulatory region variant variant in the IL27 gene.

▶

Research that mentions this SNP (2)

▶
Prognostic value of IL-27 polymorphisms and the susceptibility to epithelial ovarian cancer in a Chinese population
AssociationN=549Zhu Zhang et al.(2014)· Immunogenetics

This case-control study examined IL-27 gene polymorphisms (rs153109 and rs17855750) in 229 epithelial ovarian cancer patients and 320 healthy controls from a Chinese population. The allele G frequencies were significantly increased in cases for both SNPs (rs153109: OR=1.333, P=0.001; rs17855750: OR=1.766, P=0.001), suggesting these polymorphisms are associated with ovarian cancer susceptibility. However, these genotypes were not independent prognostic factors for 5-year survival in the patient cohort.

Traits studied:Epithelial ovarian cancer
PubMedDOIMetascience Observatory
▶
Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer
AssociationN=858Yi-Peng Tao et al.(2012)· Journal of Cancer Research and Clinical Oncology

Case-control study investigating IL-12 family and IL-12Rb1 gene polymorphisms in esophageal cancer. rs3212227 CC/AC genotype significantly increased cancer risk (OR=1.515, P=0.006), and rs568408 AG/AA and IL-12Rb1 378 GG/GC also increased risk. These variants were associated with decreased serum IL-12p40 levels, suggesting impaired immune response contributes to esophageal cancer susceptibility.

Traits studied:Esophageal cancer
PubMedDOIMetascience Observatory

About IL27

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

View all IL27 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…