IL27
interleukin 27
Summary
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1181675665 | 16:28,510,978 | C/G | — | uncertain significance |
| rs1455243109 | 16:28,511,017 | G/C | — | uncertain significance |
| rs369449099 | 16:28,511,142 | C/T | — | uncertain significance |
| rs776202759 | 16:28,511,150 | A/G | — | likely benign |
| rs1323349523 | 16:28,511,193 | C/T | — | uncertain significance |
| rs373687856 | 16:28,511,216 | G/A | — | uncertain significance |
| rs181204 | 16:28,512,524 | A/C | — | — |
| rs181205 | 16:28,513,129 | T/A | — | — |
| rs547294936 | 16:28,513,343 | G/T | — | uncertain significance |
| rs181206 | 16:28,513,403 | A/G | missense variant | — |
| rs181207 | 16:28,513,530 | C/T | downstream gene variant | — |
| rs147323193 | 16:28,515,023 | C/T | — | likely benign |
| rs373456186 | 16:28,515,102 | G/C | — | uncertain significance |
| rs201926026 | 16:28,515,113 | G/A | — | uncertain significance |
| rs1453439360 | 16:28,515,194 | C/T | — | uncertain significance |
| rs17855750 | 16:28,515,228 | A/C | missense variant | benign |
| rs1361620143 | 16:28,515,272 | C/T | — | likely benign |
| rs373160922 | 16:28,515,333 | C/G | — | uncertain significance |
| rs26528 | 16:28,517,709 | T/C | intron variant | — |
| rs749773830 | 16:28,518,122 | G/T | — | uncertain significance |
| rs153109 | 16:28,519,096 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.